Container Closure Integrity

Container integrity has always been an extremely important topic in the Pharmaceutical Industry as it represents one of the key factors for product's safety.Brevetti CEA offers integrated and stand-alone leak testing solutions for liquid and freeze-dried pharmaceutical products based on different non-invasive, non-destructive testing methods:

High Voltage Leak Detection in Liquid (HV)

Pinhole, cracks and pierced needle shield inspection can be detected by the well-known and widely proven HV principle based on the measurement of electrical conductivity of sealed containers using a high voltage electric field. LD module is the synthesis of more than thirty years of Brevetti CEA expertise in the inspection and leak detection world. Available as stand-alone machine, it can also be used in combination with our inspection machines, becoming the most compact and performing "Inspection Lines" for liquid filled ampoules, vials and cartridges available on the market.

Head Space Gas Analyzer in Freeze-dried (HGA)

Based on TDLAS spectroscopic technology, the laser is modulated in frequency to assure a more accurate, stable and reliable measurement. Light absorption is proportional to oxygen concentration in the optical path.

The system can discern oxygen-free (good) containers from the ones contaminated by oxygen due to leakage or process fault.

The installation of HGA leak detection unit into an automatic inspection machine integrates the classic detection capabilities of visual inspection and it represents the state-of-the-art in terms of leak detection in products filled under low oxygen concentration or modified atmospheres (nitrogen).